TO FIND THE PROGNOSTIC SIGNIFICANCE OF TUMOR MARGINS AND TUMOR DEPTH IN ORAL SQUAMOUS CELL CARCINOMAS – A PROSPECTIVE COHORT STUDY

Abstract

BACKGROUND: OralSquamous cell carcinomas (OSCC) are the most common type of cancers contributing for around 90%. The overall survival is below 50% for these patients. Various parameters or factors have been researched and evaluated for their significant importance and critical prognostic influence in newly diagnosed in patients with OSCC .This study evaluates the significance of histopathological parameters like tumour margins and tumour depth in prognosis of OSCC

OBJECTIVES: To find the prognostic significance of the patient based on clinic-pathological parameters like tumour margins and tumour depth in overall survival of the patient.

MATERIALS & METHODS: A prospective cohort study was performed in 25 patients with biopsy proven squamous cell carcinoma of the oral cavity who presented our hospital from August 2017 to June 2019. The data collected from their histopathological reports were tumour margins of all sides and tumour depth

RESULT: Univariate analysis was applied for various clinico-pathological parameters. Out of these parameters tumour margins greater than 5 mm had p-value 0.040, tumour depth greater than 4mm had p-value 0.860 which were not statistically significant in affecting the prognosis of the patient.

CONCLUSION- Tumour margins are found to statistically significant in affecting the prognosis of the patient. Tumour depth was not found to be statistically significant but affected the survival rate of the patient and hence both the parameters must be considered for adjuvant treatment and closefollow-up.